Multichem® AMH Control is intended for use as a third party, tri-level, liquid stable quality control material to monitor the precision of laboratory testing procedures for Anti Mullerian Hormone Assays. Anti-Müllerian hormone (AMH) is a glycoprotein belonging to the transforming growth factor-β family. AMH was named for…
Multichem® AMH Control is intended for use as a third party, tri-level, liquid stable quality control material to monitor the precision of laboratory testing procedures for Anti Mullerian Hormone Assays. Anti-Müllerian hormone (AMH) is a glycoprotein belonging to the transforming growth factor-β family. AMH was named for its first described function in fetal sex differentiation: a regression of the Müllerian ducts during early male fetal life. In males, AMH is secreted by Sertoli cells of the testes; AMH concentrations are high until puberty, and then decrease slowly to residual post-puberty levels. In the early development of the female foetus, the absence of AMH allows the Müllerian ducts to further develop, resulting in the internal female anatomy. In females, AMH is produced by granulosa cells of the preantral and small antral ovarian follicles until menopause. AMH concentrations reflect the number of small follicles entering the growth phase of their life cycle, which is indicative of the number of primordial follicles that still remain in the ovary, or the ovarian reserve.
When AMH assays were first introduced, the primary utility was to evaluate paediatric disorders such as male testicular function, ambiguous genitalia, and precocious or delayed puberty. Additionally in females, AMH was used to monitor granulosa cell tumours of the ovary. Over the last decade, the most significant use of AMH measurement has been in the evaluation of ovarian reserve to predict response to controlled ovarian stimulation in women with infertility issues.
Research studies have also demonstrated that AMH may be used to estimate the time to menopause for an individual woman, as AMH has been found to be a good indicator of reproductive aging. Additionally, studies have shown that the use of AMH may be useful in the diagnosis and monitoring of polycystic ovary syndrome.
Multichem AMH Control is designed as a tri-level, liquid stable frozen product. The product will typically be run to provide a minimum of 2 levels of control to monitor AMH assay performance within the analytical ranges. Multichem AMH Control will be run after reagent calibration and at a frequency dictated by laboratory QC procedures and reagent / instrument manufacturer instructions. The product should be treated the same as patient specimens and run in accordance with the instructions accompanying the instrument, kit or reagent being used. The Control is to be stored at -20°C to –80°C and thawed as per IFU prior to use. The product is to be stored at 2 to 8°C between use.
- Liquid stable, tri-level control
- Target values across tri- level material to monitor clinical and analytical range
- 30 days open vial stability once thawed and stored at 2 to 8 degrees
- 36 months shelf life once stored at -20 degrees
- Human based proprietary formulation
- Mimics performance of patient sample
- Unsurpassed performance and stability
- Third party independent quality control
- Commutability across all platforms
- Improved QC performance
- Improved Quality assurance
- Reduced QC packaging, storage and inventory management
|3 x 4 x 2 mL||AM500X|
|3 x 4 x 2 mL||AM500A|